Trasylol (aprotinin injection)

Made from bovine (cattle) lung tissue, the natural proteinase inhibitor Trasylol (aprotinin injection) that inhibits certain enzymes in humans that increase the risk for bleeding. Trasylol was commonly used during coronary artery bypass graft (CABG) to control bleeding. The United States Food and Drug Administration (FDA) notes that a report published on January 26, 2006 in The New England Journal of Medicine  suggests “Trasylol administration may increase the risk for serious side-effects among some patients undergoing CABG.” This report notes that more CABG patients receiving Trasylol experienced side effects (kidney damage, heart attack, and stroke) than patients receiving either no medications intended to decrease blood loss or other medications intended to decrease blood loss.

An article published by CBS News on February 11, 2009, details the aggressive marketing or, the widespread use of, and the serious problems associated with Trasylol. This article states the following: “The FDA approved Trasylol for patients at high risk of bleeding and it noted kidney toxicity was a problem. Bayer pushed the drug hard. In 1998, the FDA expanded its approval to cover all heart bypass patients. By 2005, sales of the drug hit $300 million. The next year, $750 million was projected, and Bayer envisioned a billion-dollar drug.” This article quotes Dennis T. Mangano, Ph.D., M.D. with the following statement: “Between my study and November 5, when it was taken off the market, there were approximately 431,000 patients who received the drug. As I calculated, 22,000 lives could have been saved. It’s about a 1,000 lives saved per month delay in taking that drug off the market,” he says.”

On November 5, 2007, Bayer AG suspended worldwide sales of Trasylol. Bayer has been settling many lawsuits since then. As of 2013, it’s unlikely at this time that any new lawsuits would be brought. However, if you live in California, have not already hired a lawyer, and have questions about settlement with Bayer as a result of Trasylol, you should know that attorney and physician Paul J. Molinaro is available to answer your legal questions. You can reach Paul J. Molinaro, M.D. J.D. toll free at (888)MDJDLAW.

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